The effect of divergent selection on the basal metabolic rate on body temperature in males of laboratory mice with different levels of obesity
不同肥胖程度實(shí)驗(yàn)室雄性小鼠基礎(chǔ)代謝率對(duì)體溫的影響
Abstract
Objectives
Basal metabolic rate (BMR) and body temperature are evolutionarily coupled in mammals. Low values of both BMR and body temperature, and high lability (instability) of body temperature in response to unfavorable conditions are important predictors of obesity risk. Therefore, clarifying their mutual dependencies is important for interpreting the results of translational studies. The aim of our study was to determine how large intraspecific variation in BMR affects body temperature and its lability in laboratory rodents with different levels of obesity.
Methods
We measured core body temperature by means of implanted loggers in males from two lines of laboratory mice divergently selected for high (H-BMR) or low (L-BMR) BMR and acclimated to 23?°C and 4?°C.
摘要：
目標(biāo)
基礎(chǔ)代謝率（BMR）與體溫在哺乳動(dòng)物中具有進(jìn)化上的關(guān)聯(lián)性。BMR和體溫的低值，以及體溫在不利條件下表現(xiàn)出的高波動(dòng)性（不穩(wěn)定性），都是肥胖風(fēng)險(xiǎn)的重要預(yù)測(cè)指標(biāo)。因此，明確二者間的相互依賴關(guān)系對(duì)于解讀轉(zhuǎn)化研究結(jié)果至關(guān)重要。本研究旨在探討BMR的物種內(nèi)變異如何影響不同肥胖程度實(shí)驗(yàn)嚙齒動(dòng)物的體溫及其波動(dòng)性。
方法
我們通過(guò)植入記錄儀測(cè)量了來(lái)自兩個(gè)實(shí)驗(yàn)室小鼠品系的雄性小鼠的核心體溫，這兩個(gè)品系分別選擇了高（H-BMR）或低（L-BMR）BMR，并適應(yīng)了23℃?°C和4?°C.
